The term "vasculitis" refers to a large group of diseases that are partially similar to the diffuse connective tissue diseases.
Causes immune-mediated mechanisms of inflammation of the blood vessels are infection, drugs, malignancies. For symptoms of vasculitis in children characterized hemorrhagic palpable rash in the absence of thrombocytopenia, arthritis, fever, myalgia, fatigue, decrease or pathological increase in body weight, increased ESR. Besides the skin affects the joints, lungs, kidneys, CNS.
Disease Henoch-Schonlein Purpura
Hemorrhagic vasculitis in children of school age appears hemorrhagic rash, mainly on the legs and buttocks. Infantile hemorrhagic edema, which occurs in children up to 3 years, similar in something with hemorrhagic vasculitis, but has some differences. The rash of it are clearly delineated and hemorrhagic papules and plaques located on the trunk and extremities. In contrast to hemorrhagic vasculitis, observed eruptions on the face, but internal organs are not affected. In the differential diagnosis of hemorrhagic vasculitis include infection with hemorrhagic rashes: meningococcal sepsis, Rocky mountain spotted fever, hemorrhagic rash, caused by enteroviruses, rheumatoid arthritis, other vasculitides in children.
The clinical picture of Kawasaki disease consists of cutaneous and waconah symptoms of vasculitis in children. Polymorphous skin rash — blisters, spots, papules, and morbilliform erythema, plaques on the trunk and extremities. The rash starts in the groin creases that pathognomonic for this disease. Another characteristic symptom of vasculitis in children — swelling and peeling of the hands and feet, but they appear later. The typical lesions of mucous membranes, conjunctivitis, is usually not spectacular limb of the cornea, and plaques on the mucosa of the tongue ("white strawberry tongue"), which are exfoliated. Language becomes bright, with protruding papillae ("strawberry tongue"). Histological changes in the skin are nonspecific and do not facilitate the differential diagnosis with viral or bacterial asanteman and drug rashes.
A systemic disease characterized by ulceration of the oral mucosa, genital, eye lesions (uveitis, recurrent iridocyclitis). In 98% of cases observed recurrent aphthous stomatitis is the most common symptom of vasculitis in children. Ulceration on the genitals resemble aphthae. In men they are located on the penis and the scrotum. In women, rashes in the genital area is especially painful. In addition, lesions of the skin include folliculitis, hemorrhagic vasculitis, nodular erythema, pustules in the field of venepuncture and minor injuries. The differential diagnosis of changes in the mucosa of the oral cavity includes aphthous stomatitis, herpes, and relatively rare syndromes with a lesion of the mucous membranes and the eyes, such as the MAGIC syndrome (an acronym for "mouth and genital ulcers with inflamed cartilage" — ulceration of the mucous membrane of the mouth, genitals and inflammation of cartilage), skin Biopsy reveals lakokrasochnyi or lymphocytic vasculitis. The defeat of the oral mucosa is eliminated medicinal products for sucking or chewing include corticosteroids, antihistamines, antibiotics and analgesics.